Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.
|Etsushi Toyokawa||Airi Taira||Naohito Fujiki||Takako Tokiwa||Teruyuki Kagawa|
|Yusuke Santamaria||Mirai Moriyama||Haruka Kinami||Hitomi Kuroki|
|Sadakiyo||Kakuda (manga artist)||Kyoko||Kirko Endo (Kenji's sister)|
Additional Cast Members: